Search results for "mesolimbic system"

showing 3 items of 3 documents

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

2017

After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central e…

0301 basic medicineCognitive Neuroscienceethanol acetaldehyde salsolinol ethanol metabolism epigenetics neuroinflammation mesolimbic system dopamineReviewPharmacologyConsumption (sociology)neuroinflammationlcsh:RC321-571Developmental psychologyethanol metabolism03 medical and health sciencesBehavioral Neurosciencechemistry.chemical_compound0302 clinical medicineEthanol metabolismsalsolinollcsh:Neurosciences. Biological psychiatry. NeuropsychiatryepigeneticsAcetaldehyde030104 developmental biologyNeuropsychology and Physiological Psychologymesolimbic systemchemistryethanoldopaminePsychology030217 neurology & neurosurgeryNeuroscienceacetaldehydeFrontiers in Behavioral Neuroscience
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Glutamate and opioid antagonists modulate dopamine levels evoked by innately attractive male chemosignals in the nucleus accumbens of female rats

2017

Sexual chemosignals detected by vomeronasal and olfactory systems mediate intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic pathway processes natural rewards, and the nucleus accumbens receives olfactory information via glutamatergic projections from the amygdala. Thus, the aim of this study was to investigate the involvement of the mesolimbic pathway in the attraction toward sexual chemosignals. Our data show that female rats with no previous experience with males or their chemosignals display an innate preference for male-soiled bedding. Focal administration of the opioid antagonist b-funaltrexamine into the posterior ventral tegmental area does no…

0301 basic medicinemedicine.medical_specialtySexual attractionmedicine.drug_classSistema nerviós central MalaltiesNeuroscience (miscellaneous)olfactory systemMesolimbic pathwayNucleus accumbensAmygdalaNaltrexonePheromones03 medical and health sciencesCellular and Molecular NeuroscienceFeromones0302 clinical medicineNeurochemicalRewardDopamineInternal medicinemedicinerewardOriginal ResearchMesolimbic systemsexual attractionOlfactory systemVentral tegmental areaNeuroanatomy030104 developmental biologymedicine.anatomical_structureEndocrinologymesolimbic systemAnatomypheromonesPsychologyNeuroscience030217 neurology & neurosurgeryOpioid antagonistTecnologia farmacèuticamedicine.drug
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Cannabis and the Mesolimbic System

2016

Abstract Cannabis sativa (hemp) is a flowering annual plant whose phytochemical by-products, hashish and marihuana, are the most widely produced and most frequently used illicit drugs in Europe. Δ 9 -Tetrahydrocannabinol is the primary psychoactive constituent, responsible, in a dose-related manner, for euphoria, cognitive effects, and psychotic symptoms, as well as the addictive potential of smoked cannabis due to its interference with the mesolimbic dopaminergic system. Cannabis as well as endocannabinoids acts mainly at the presynaptic levels in several brain regions, including the nucleus accumbens and ventral tegmental area, where it modulates synaptic activity. Through the modulation …

CB1 receptorCannabinoid receptorDopaminergic transmissionmedicine.medical_treatmentHashishNucleus accumbensPharmacologymedicineCannabiDependenceTetrahydrocannabinolMesolimbic systembiologyMedicine (all)food and beveragesbiology.organism_classificationEndocannabinoid systemVentral tegmental areamedicine.anatomical_structure9-THCWithdrawalCannabinoidCannabisPsychologyNeurosciencemedicine.drug
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